Oecd Guidelines for the Testing of Chemicals

ثبت نشده
چکیده

1. OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The concept of the up-and-down testing approach was first described by Dixon and Mood (1)(2)(3)(4). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). There exist several variations of the upand-down experimental design for estimating an LD50. This guideline is based on the procedure of Bruce as adopted by ASTM in 1987 (6) and revised in 1990. A study comparing the results obtained with the UDP, the conventional LD50 test and the Fixed Dose Procedure (FDP, OECD Test Guideline 420) was published in 1995 (7). Since the early papers of Dixon and Mood, papers have continued to appear in the biometrical and applied literature, examining the best conditions for use of the approach (8)(9)(10)(11). Based on the recommendations of several expert meetings in 1999, an additional revision was considered timely because: i) international agreement had been reached on harmonized LD50 cut-off values for the classification of chemical substances, ii) testing in one sex (usually females) is generally considered sufficient, and iii) in order for a point estimate to be meaningful, there is a need to estimate confidence intervals (CI).

منابع مشابه

Oecd Guideline for the Testing of Chemicals

1. The OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress, changing regulatory needs and animal welfare considerations. The original Test Guideline 487 was adopted in 2010; it has been revised in the context of an overall review of the OECD Test Guidelines on genotoxicity. A document presented as an Introduction to the Test Guidelines on g...

متن کامل

OECD GUIDELINE FOR THE TESTING OF CHEMICALS PROPOSAL FOR UPDATING TEST GUIDELINE 473 In Vitro Mammalian Chromosomal Aberration Test

1. The OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress, changing regulatory needs, and animal welfare considerations. The original Test Guideline 473 was adopted in 1983. In 1997 a revised version was issued, based on scientific progress made to that date. Modifications within the current version reflect nearly thirty years of experienc...

متن کامل

OECD GUIDELINE FOR TESTING OF CHEMICALS Proposal for a New DRAFT GUIDELINE 434: Acute Dermal Toxicity – Fixed Dose Procedure

1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress and animal welfare considerations. The original acute Dermal Toxicity Guideline TG 402 (1) was adopted in 1987. Development of a dermal Fixed Dose Procedure (FDP) was considered appropriate, following adoption of the revised Oral FDP, OECD Guideline 420 (2) and deletion of OECD Guidelin...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

متن کامل
عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008